RSA Laboratories

 

The RSA Laboratories have a two-fold function: to work in conjunction with manufacturing, performing preliminary suitability and pre scale-up studies, and to perform as a stand-alone unit engaging in process development and custom syntheses from gram to kilo quantities. All laboratory activities are conducted under GLP and cGMP guidelines.

 

The diversity of synthetic steps conducted in our laboratories precludes a complete listing of reactions.  A Broad range of R&D operations includes pressure reactions to 2000 psi, hydrogenations, fractional distillations, Birch reductions, Diels-Alder cyclizations, Wittig reactions, Grignard reactions, esterifications, halogenations, hydride reductions, diazotization, N & O alkylation, acylations and polymerizations. A comprehensive equipment inventory includes:

 

• Up to 72 liters for synthesis and fractional distillation
• 1500 psi SS autoclave
• 2 liter, 2000 psi hastelloy reactor with magnetic drive
• 2 liter, 2000 psi SS reactor with magnetic drive
• Several distillation heads equipped with automatic reflux splitters
• Several vacuum systems beginning at less than 100 microns

Analytical methods development and validation are ongoing programs in our QC and R&D laboratories.  A broad spectrum of available instrumentation facilitates these programs and includes:

 

• FTIR Spectrophotometer
• UV/Vis Spectrophotometer
• Several Capillary Gas Chromatographs with Split/Splitless Injectors and FIDs
• High Performance Liquid Chromatograph
• Computer systems for data collection, retrieval and reports